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Sir is an honorific address used in a number of situations in many anglophone cultures. The term can be used as a formal prefix, especially in the Commonwealth , for males who have been given certain honours or titles (such as knights and baronets ), where usage is strictly governed by law and custom.
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Once one is able to model an infectious pathogen with compartmental models, one can predict the various properties of the pathogen spread, for example the prevalence (total number of infected from the epidemic) and the duration of the epidemic. Also, one can understand how different situations may affect the outcome of the epidemic, e.g., what is the best technique for issuing a limited number of vaccines in a given population?